EAYH Lecture 8 Sept 27 - 17/10/2011 10:52:00 ← Lecture 8...

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Unformatted text preview: 17/10/2011 10:52:00 ← Lecture 8 ← 9/20/11 ← ← ← Choose article from PubMed. It must be related to “Environment” and “Health,” not “Public Health.” ← Last name A-M take exam on Thursday in Hodson; N-Z in Remsen 101. ← ← Must log-in under Hopkins domain to view full article. ← ← Write 400-500 word article to 8-10 th grade reading level. ← ← Must get article approved by TAs – either send to course email address or bring it into class and show the TA's. Don't wait until the last minute! ← ← Exams will probably be returned by next Tuesday. ← ← What happens AFTER exposure? Processes Associated with Toxicokinetics of Agents ← The Toxicological Process ← ← T = biologically effective dose ← We can store chemicals – stored in the FAT and BONE ← ← bone can't tell difference between calcium and lead ← ← Biologically effective dose of active form interacts with target, target becomes altered, then you get the responses. ← ← The more molecules affected, the more effects. ← ← Repair : you can repair at the molecular level, organs, DNA, etc. Liver can be repaired really well. Eventually it gets to a point where it cant fix itself- you get trouble. ← ← Exercise turns on brain cells and helps them repair! ← ← Toxicokinetics : ← Absorption : taking in of a chemical from a site(s) of exposure resulting in an internal dose ← Distribution : distributing a chemical from its site of absorption throughout the body ← Excretion : removing the chemical from the body ← Biotransformation : enzymatic modification of chemicals ← can be good (to make water-soluble) or bad process (may make chemicals toxic) ← Absorption: membrane Transport of Xenobiotics ← involves taking things in and passing them through membranes to reach organ cells ← reason things are toxic is that they are ← can move things through different membranes: ← mucosa or skin ← capillary membrane (smallest blood vessels in the body – where exchange between blood cells and organs go on) ← move through plasma (water part of blood) ← target cell membrane ← sub-cellular organelle membrane ← ← ← ← ← Types of transport (mechanisms through which things are absorbed/transported through membranes) ← simple diffusion * most common* ← take in things via diffusion because they are lipid-soluble , often then stored in fat ← facilitated diffusion ← active transport ← pinocytosis/receptor-mediated uptake ← filtration ← ← Both PASSIVE mediated (facilitated) and ACTIVE mediated transport involve the use of CARRIER PROTEINS. ← ← Active transport uses ATP as an energy source for the carrier. ← ←...
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This note was uploaded on 01/19/2012 for the course PUBLIC HEA 280.335 taught by Professor Dr.trush during the Fall '11 term at Johns Hopkins.

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EAYH Lecture 8 Sept 27 - 17/10/2011 10:52:00 ← Lecture 8...

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