EAYH Lecture 9 Sept 29 - 17/10/201110:52:00 Lecture9 9/29/11

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
17/10/2011 10:52:00 Lecture 9 9/29/11 Toxicodynamics of Environmental Carcinogenesis Don't expect to get email back within 1.5 days. REVIEW Assignment instructions  before selecting article. Need PRIMARY evidence (not review journal!) Must look at  issue at first time – methods, results, discussion, etc. Make sure that 1 st  article you want  to send is the one you want to do. Attach the LINK of the article the first time around.  Environmental exposure and health outcome. Socioeconomic status is not directly  environmentally-implicated.  Last two lectures were focused on chemicals and what happens to chemicals in  the body. Now, we're going to talk about those concepts in context of cancer. Remember: The  Epidemiological Transition  chronic diseases have surpassed infectious conditions and they are increasing.  Cancer is one of these chronic diseases. This is occurring around the world. The Toxicological Paradigm Toxicokinetics: Exposure  internal dose  Biologically effective dose – dose that interacts with target and leads to problems  Toxicodynamics: early biological effects  altered structure/function 
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
disease  all of above are susceptibility factors  Toxicodynamics  refers to the molecular, biochemical, and physiological effects  of toxicants or their metabolites in biological systems  These effects are result of the interaction of the biologically effective dose of the  ultimate (active) form of the toxicant with a molecular target For cancer,  DNA  is the primary target The causes of cancer: Breathing (continuous exposure) oxygen you breathe – radicals radicals related to inflammation  particles  carcinogens/air pollutants Eating  OBESITY is very linked to cancer Drinking chlorinated water – generates some carcinogenic chemicals Radiation  sunlight ionizing radiation  Sex
Background image of page 2
transmit certain viruses or bacteria AIDS – can develop tumors because they are immunosuppressive  Doctors  many drugs we're given cause cancer  many drugs used to treat cancer cause SECONDARY cancer!  Parents  can be genetically disposed  Carcinogenesis: The Process  What causes it? Exogenous: chemicals, radiation, viruses endogenous: hormones, immune dysfunction  inherited mutations (susceptibilities) Cancers that arise from accumulation of genetic damage  Only 5-15% of cancer is inherited  The  inheritance of single mutated genes  are necessary and sufficient for  disease: BRCA- involved in DNA repair (breast/ovary  cancer)
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 01/19/2012 for the course PUBLIC HEA 280.335 taught by Professor Dr.trush during the Fall '11 term at Johns Hopkins.

Page1 / 16

EAYH Lecture 9 Sept 29 - 17/10/201110:52:00 Lecture9 9/29/11

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online