Lecture 4

Lecture 4 - Synapses Synapses=Special connections between...

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Synapses Synapses=Special connections between neurons for signaling I) Chemical Synapses a. Structure a.i. Presynaptic nerve-terminal a.i.1. Synaptic vesicles a.i.2. containing neurotransmitters (NT) a.ii. Postsynaptic neuron a.ii.1. Concentrated NT receptor (transmembrane protein) b. Synaptic Transmission b.i. AP in presynaptic nerve induces release of NT’s by exocytosis of SV b.ii. NT’s diffuse across synaptic space b.iii. NT’s bind to NT receptros on postsynaptic neuron b.iii.1. opens channels b.iv. Ion flow through chemical PSP’s II) Model example: Neuromuscular Junction (NMJ) (Motor neuron in spinal cord sends axon to muscle fiber and makes a synapses on the fibers) a. NMJ chemistry a.i. NT=acetylcholine (ACh) a.i.1. Made in nerve terminal a.i.1.a. Choline + Acetyl-COA ACh +COA a.i.2. Pack into Synaptic Vesicles (SV’s) a.ii. Postsynaptic Receptors a.ii.1. Nicotine AChR’s (nAChR’s) a.ii.1.a. ACh receptors a.ii.1.b. Or nAChR’s) a.ii.2. Ace ion channels (Open 00>Na+ K+ flow)
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This note was uploaded on 01/17/2012 for the course HILD 100 taught by Professor Lee during the Spring '11 term at UCLA.

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Lecture 4 - Synapses Synapses=Special connections between...

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