09.06.11 - Welcome to BIO305: Genetics Lectures: Tuesday...

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Unformatted text preview: Welcome to BIO305: Genetics Lectures: Tuesday and Thursday 8:40-10:00 Natural Science Auditorium Tim James Anuj Kumar tyjames@umich.edu 1147 Natural Science Bldg. anujk@umich.edu 4071D Natural Sciences Building GSIs: Pia Bagamasbad: piab@umich.edu Karan Bedi: bedik@umich.edu Kerry Flegel: kerryann@umich.edu Ann Marie Macara: macara@umich.edu 1. In 1866, Gregor Mendel showed that: traits can be inherited as discrete units ( genes ) that are equally contributed from the mother (egg) and father (pollen) and these traits undergo independent segregation during gamete formation. in other words, he discovered diploidy of the body and haploidy of the gametes 2. DNA is the biological information molecule organized in many ways like books. letter -> nucleotide paragraph -> gene locus -> section chromosome -> chapter genome -> book population -> library translation -> interpreter human genome 3. Central dogma of genetics+ DNA->RNA->protein->phenotypes->whole organism fitness replication transcription translation epigenetics epistasis fitness population genetics phylogeny 4. Applications of genetics Using genetics to answer biological questions: What is the function of a given gene? What genes are required for various biological processes? What genes are contributing to complex traits? And also be put to good use for humanity: Personalized medicine Industrial production of enzymes Genetics screens Forensics Genetically modified organisms Gene therapy Business part of 305 Instructors Tim James, 1147 Natural Science Building, tyjames@umich.edu Anuj Kumar, 4071D Natural Sciences Building, or LSI 6026, anujk@umich.edu Office hours James: Wednesday 3-6 PM Kumar: Tuesdays, Thursdays, 10-11:30 AM CTools website...
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09.06.11 - Welcome to BIO305: Genetics Lectures: Tuesday...

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