EnzymeKinetics_000

EnzymeKinetics_000 - Enzyme Kinetics Law Depends on...

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Enzyme Kinetics
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Law Depends on Mechanism Remember our previous example If first mechanistic step is rate determining, rate law can be written from O3 + 2 NO2 O2 + N2O5 1. O3 + NO2 NO3 + O2 slow 2. NO3 + NO2 N2O5 fast Rate = k[O3][NO2]
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More Complex Mechanism What if the second step is rate limiting? What if RDS is unknown? Using the Steady State Approximation , we can write a general rate law and determine which RDS fits the experimental evidence Your book presents steady state and other techniques, but steady state assumption works well for all situations generally encountered
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Breakdown of Ozone O3 O2 + O O + O3 2O2 Rate = k2[O][O3] but O is an intermediate. How do we determine [O]? k1 k-1 k2
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Steady State Approximation Assumption: concentration of intermediates stays about constant during reaction Low, constant [Intermediate] Rate of appearance = rate of disappearance For this mechanism: O3 O2 + O O + O3 2O2 k1[O3] = k-1[O2][O] + k2[O][O3] k1 k-1 k2
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EnzymeKinetics_000 - Enzyme Kinetics Law Depends on...

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