AldolreactionConditions

AldolreactionConditions - Effect of Reaction Conditions on...

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Effect of Reaction Conditions on the Aldol Reaction Question: How do reaction conditions of temperature and choice of base affect the outcome of an aldol reaction? Background The aldol reaction is a very important means of making carbon-carbon bonds. Under basic conditions, the protons of ketones, aldehydes, and esters may be removed to form strong nucleophiles that can then add to another compound containing a carbonyl. While this can lead to a mixture of products, there are ways to favor formation of one product. For example, if a ketone is mixed with an aldehyde containing no protons, there is only one possible nucleophile. Furthermore, the aldehyde is a much better electrophile than a ketone under these conditions, so the aldehyde serves as the electrophile. An example of such a “crossed Aldol” reaction is shown below: N O + H O NO 2 catalytic base ? The outcome of any reaction depends on the reaction conditions. Choices of solvents, temperatures, and bases can lead to an effective or ineffective reaction. In some cases,
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AldolreactionConditions - Effect of Reaction Conditions on...

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