lecture 15 - Examples of biologically relevant compounds...

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Where does inorganic chemistry lead?
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Further coursework Chemistry 416 – transition metal chemistry (J. Mayer) Chemistry 417 – organometallic chemistry (K. I. Goldberg) Biochemistry 405/406 (also known as Chemistry 255/256 at North Seattle CC) – biochemistry (T. Furutani)
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Bio-inorganic chemistry Studies of the interaction of metals (typically transition metals) with biochemicals Wide range of interactions – structural (magnesium in a porphyrin ring in chlorophyll; “zinc fingers”) to electron transport (iron-sulfide and copper within carrier proteins)
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Metalloenzymes contain metal ions attached to proteins via amino acid ligands Histidine (amino acid) ligand Cysteine (amino acid) ligand
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The active site of an enzyme that evolves H 2
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electron transport active site
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electrons are funneled to the catalytic site via the Fe 4 S 4 clusters
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Examples of biologically relevant compounds with
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Unformatted text preview: Examples of biologically relevant compounds with these ligands these ligands Fe His N His N His N O Fe N His N His O O O O Glu Asp II II H thiolate ligand imidizole ligand bridging carboxylate ligand N his Cu S cys N his S met blue copper electron transport electron transport oxygen transport Plastocyanin – an electron transporter Two nitrogen and two sulfur atoms stabilize a copper atom Called a “blue copper site” for its reflected color The symmetry of the active site X-ray crystallography classified this as a distorted T d point group It was expected that the Cu d x 2-y 2 and the ligand p z orbitals would mix to give the desired geometry; however, EPR spectroscopy showed no p z orbital contribution — ligands were arranged around the Cu d x 2-y 2 orbital. Thus, the geometry is actually D 4h – more...
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