section20

section20 - MIT Department of Biology 7.014 Introductory...

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MIT Department of Biology 7.014 Introductory Biology, Spring 2005 Recitation Section 20 April 25-26, 2005 Immunology A. Antibody production Shown below is a schematic of the production of a heavy chain polypeptide for an antibody. At the top is the chromosomal arrangement found in an immature B cell, at the bottom is shown the heavy chain polypeptide. V segments D segments J segments constant segment = intron regions 1. Label the process indicated by each arrow. Choose the one best option for each from: protein processing transcription translation transduction DNA ligation DNA rearrangement RNA splicing RNA ligation 2. Indicate on the diagram below where you would expect to find each of the following components: promoter Transcription terminator start codon stop codon 3. Indicate on the diagram below the variable and the constant region of the heavy chain polypeptide. 1
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An activated B cell undergoes cell division and produces many daughter cells. Some daughter cells will function as B cells, some will function as plasma cells and other will become memory cells. 4. Assume that an activated B cell undergos somatic mutation and produces two different B cells each with a slightly altered version of the antibody. This event occurs early in the immune response ( i.e. when antigen was present in the organism). Mutation A makes the antibody-
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section20 - MIT Department of Biology 7.014 Introductory...

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