OPPPGlycogenRegulation2009

OPPPGlycogenRegulation2009 - 10/30/2009 The Oxidative...

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10/30/2009 1 The O xidative P entose P hosphate P athway Provides NADPH and Riboses for biochemical syntheses. It has a nonoxidative and an oxidative phase . It helps to maintain a reduced environment in certain cell types. A defect in the key enzyme glucose 6-phosphate DH has severe consequences on human health. The R eductive P entose P hosphate P athway Participates in Plant Photosynthesis. Maintaining a Reduced Cell Environment Protecting cells against reactive oxygen Box 14-4
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10/30/2009 2 The OPPP can be divided into two phases Fig. 14-20 The oxidative reactions of the OPPP Note Products! Fig. 14-21
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10/30/2009 3 Glucose 6-P Dehydrogenase Reaction Fig. 14-21 Lactonase Reaction Fig. 14-21
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10/30/2009 4 6-P-gluconate DH Reaction Fig. 14-21 P-Pentose Isomerase Reaction Fig. 14-21
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10/30/2009 5 In some tissues OPPP ends with Ribose Formation Glucose 6-P + 2NADP + + H 2 O Ribose 5-P + CO 2 + 2NADPH + 2H + In tissues requiring mostly NADPH, Pentose Phosphates are recycled into Glucose 6-P Six Riboses are converted into Five Hexoses Fig. 14-22b
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10/30/2009 6 Key Enzymes: Transketolase and Transaldolase Fig. 14-22a First, Ribulose 5-P is converted to Xylulose 5-P
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10/30/2009 7 Transfer of a two carbon fragment from a Ketose to an Aldose Transketolase requires TPP. (Or successful schemes repeat in nature.) Fig. 14-23 The 1 st Reaction Catalyzed by Transketolase Fig. 14-23
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10/30/2009 8 Transaldolase Catalyzes a Condensation between a Three-carbon Unit and an Aldehyde Fig. 14-24 The 2 nd Reaction Catalyzed by Transketolase Fig. 14-25
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10/30/2009 9 Resonance Stabilized Carbanions Fig. 14-26
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10/30/2009 10 Feedback Regulation of Glucose 6-P DH Fig. 14-27
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10/30/2009 11 David L. Nelson and Michael M. Cox LEHNINGER PRINCIPLES OF BIOCHEMISTRY Fifth Edition CHAPTER 15 © 2008 W. H. Freeman and Company Principles of Metabolic Regulation Pathways are connected
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10/30/2009 12 Metabolic Networks Fig. 15-1 Metabolism of Glycogen in Animals as Paradigm for Regulation of Metabolism Muscle versus Liver Glycogen Fig. 15-24 Glycogen granules in hepatocyte
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10/30/2009 13 Glycogen Breakdown Fig. 15-26 Removal of glucose from the non-reducing end Fig. 15-26
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OPPPGlycogenRegulation2009 - 10/30/2009 The Oxidative...

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