TCACycle2009 - 1 LEHNINGER David L. Nelson and Michael M....

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Unformatted text preview: 1 LEHNINGER David L. Nelson and Michael M. Cox LEHNINGER PRINCIPLES OF BIOCHEMISTRY Fifth Edition CHAPTER 16 2008 W. H. Freeman and Company The Citric Acid Cycle Natures Oxygen/Carbon Cycle O 2 Respiration Photosynthesis O 2 CO 2 CO 2 Carbs H 2 O H 2 O 2 The Three Stages of Cellular Respiration Fig. 16-1 3 4 Overall Reaction Catalyzed by the Pyruvate DH Complex Fig. 16-2 The Overall Reaction Catalyzed by the Pyruvate DH Complex is an Oxidative Decarboxylation. This step is irreversible. Compare to Pyruvate Decarboxylase (Fermentation) Chapter 14.3 5 The Pyruvate Dehydrogenase complex requires 5 Coenzymes Thiamine Pyrophosphate (TPP) Corresponding Vitamins: Thiamine Flavin Adenine Dinucleotide (FAD) Coenzyme A (CoA) Nicotinamide Adenine Dinucleotide (NAD) Lipoate Riboflavin Pantothenate Niacin Thiamine deficiency causes Beriberi The aerobic oxidation of glucose/pyruvate in the brain is impaired causing the loss of neural function Remember TPP from Chapter 14 (Fermentation)? Fig. 14-14 6 Coenzyme A, a Cofactor of Pyruvate DH Fig. 16-3 Acetyl-CoA is a thioester 7 Lipoic Acid, a Cofactor of Pyruvate DH oxidized Amide Bond reduced Fig. 16-4 The Pyruvate Dehydrogenase is a Protein Complex made up of three major proteins: 1: Pyruvate Dehydrogenase E1...
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This note was uploaded on 01/17/2012 for the course NSC 461 taught by Professor Benning during the Fall '11 term at Michigan State University.

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TCACycle2009 - 1 LEHNINGER David L. Nelson and Michael M....

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