2009-09-14_-_Lecture_5

2009-09-14_-_Lecture_5 - Biochemistry 461 FS 2009 Michigan...

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Biochemistry 461 FS 2009 Michigan State University Proteins: Secondary Structure September 14, 2009 Lecture 5 Proteomics: The study of the entire complement of proteins found in a particular tissue or cell type. • One approach to study the proteome of an organism is based on two- dimensional gel electrophoresis followed by mass spectrometry. Proteomics (from previous lecture) 2
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BLAST Can Be Used to Find Homologs 3 www.ncbi.nlm.nih.gov • Homologs = • Paralogs = • Orthologs = 4 Homologs, Paralogs and Orthologs (from previous lecture)
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Identifying Important Residues (from previous lecture) 5 Protein sequences and evolution (from previous lecture) 6
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Properties of Peptide Bonds • Peptide bonds are delocalized! 7 Consequences of Delocalization • Because of delocalization, peptide bonds are: ¾ ¾ 8
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The Peptide Bond Is Rigid and Planar • The 3 dimensional orientation of a polypeptide can be defined by the angles φ and ψ . • But what exactly are phi and psi?
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2009-09-14_-_Lecture_5 - Biochemistry 461 FS 2009 Michigan...

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