Biochemistry 461FS 2009Michigan State UniversityCatalytic StrategiesOctober 2, 2009Lecture 12•Irreversible inhibitionrefers to the formation of a (usually) covalent bond between inhibitor and enzyme that prevents activity. Irreversible inhibitors often modify a functional group that is essential for activity.•A subclass of irreversible inhibitors are mechanism-based or suicide inhibitors, pseudosubstrates that undergo the preliminary steps of catalysis before combining irreversibly. •These can be very informative in mechanistic studies.Irreversible Inhibition(from previous lecture)2
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