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2009-10-02_-_Lecture_12 - Biochemistry 461 FS 2009 Michigan...

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Biochemistry 461 FS 2009 Michigan State University Catalytic Strategies October 2, 2009 Lecture 12 Irreversible inhibition refers to the formation of a (usually) covalent bond between inhibitor and enzyme that prevents activity. Irreversible inhibitors often modify a functional group that is essential for activity. A subclass of irreversible inhibitors are mechanism-based or suicide inhibitors, pseudosubstrates that undergo the preliminary steps of catalysis before combining irreversibly. These can be very informative in mechanistic studies. Irreversible Inhibition (from previous lecture) 2
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