2009-10-05_-_Lecture_13

2009-10-05_-_Lecture_13 - Biochemistry 461 FS 2009 Michigan...

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Biochemistry 461 FS 2009 Michigan State University Regulation of Enzymes October 5, 2009 Lecture 13 Enzyme Activity Depends on pH (from previous lecture) • Shape of rate versus pH is often bell-shaped • A change in activity often reflects titration of an important residue in catalysis, structure, or substrate binding • Caution: in the environment of a protein, the p K a of the amino acid side chains can be significantly altered 2
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Enzyme Activity Depends on pH (from previous lecture) 3 Regulating Enzyme Activity • Why regulate enzyme activity? ¾ The “control of catalysis is critical to life” ¾ Chemical energy must be used economically ¾ It is wasteful to make metabolites, etc. that are not needed ¾ Chemical energy is “parceled out to various metabolic pathways as cellular needs dictate” • What are the strategies utilized by the cell to regulate enzyme activity? ¾
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This note was uploaded on 01/17/2012 for the course NSC 461 taught by Professor Benning during the Fall '11 term at Michigan State University.

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2009-10-05_-_Lecture_13 - Biochemistry 461 FS 2009 Michigan...

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