MICRO 06 Lect 6

MICRO 06 Lect 6 - LECTURES IN MICROBIOLOGY Microbial...

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Microbial Metabolism Sofronio Agustin Professor LECTURES IN MICROBIOLOGY LESSON 6
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2 Lesson 6 Topics Metabolism Energy Pathways Biosynthesis
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3 Metabolism Catabolism Anabolism Enzymes
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4 Catabolism Breakdown of complex organic molecules in order to extract energy and form simpler end products. Enzymes are involved.
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5 Metabolism Model
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6 Enzymes Function Structure Enzyme-substrate interaction Cofactors Action Regulation
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7 Enzyme Structure Simple enzyme - primarily protein Conjugated enzyme - protein and nonprotein Three-dimensional features: Specificity -”lock-and-key” Active site or catalytic site
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8 Conjugated Enzymes Conjugated enzymes contain a metallic cofactor, coenzyme, or both in order for it to function as a catalyst.
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9 Active Site Specific active sites are folded regions of the protein molecule and contain specific amino acids in its microenvironment.
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10 Enzyme-Substrate Interaction Substrates specifically bind to the active sites on the enzyme: -“lock-and-key” style -Induced fit Once the reaction is complete, the product is released and the enzyme reused.
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11 Lock-and-Key Model Specificity of enzyme-substrate reactions and induced fit.
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12 Coenzymes Function as transient carriers Alter a substrate by removing a chemical group from it and adding it to another. Ex. NAD, FAD and CoA
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13 Coenzyme Activity Carrier function of coenzymes A coenzyme transfers chemical groups from one substrate to another.
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14 Enzyme Action Exoenzymes Endoenzymes Constitutive Induction or repression Types of reactions
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15 Enzyme Location Exoenzymes are inactive while inside the cell, but upon release from the cell they become active. Endoenzymes remain in the cell and are always active.
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16 Constitutive and Regulated Enzymes Constitutive enzymes are present in constant amounts.
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This note was uploaded on 01/18/2012 for the course MCB 2010C taught by Professor Sofronioagustin during the Fall '06 term at Valencia.

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MICRO 06 Lect 6 - LECTURES IN MICROBIOLOGY Microbial...

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