MICRO 06 Lect 12

MICRO 06 Lect 12 - LECTURES IN MICROBIOLOGY Host Defense...

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Host Defense Mechanisms Sofronio Agustin Professor LECTURES IN MICROBIOLOGY LESSON 12
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2 Topics Nonspecific Resistance: (1) Intact skin, mucous membranes, normal microbiota. (2) Phagocytic leukocytes, inflammation, fever Specific Resistance: (1) Antibodies (2) Specialized T- and B-cells
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3 Terms Susceptibility vulnerability of the host to disease Resistance ability of the host to ward off disease Nonspecific resistance host defenses against any pathogen Specific resistance host defenses against a specific pathogen
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4 Mechanical Factors Skin Epidermis consists of tightly packed cells with protective layer of keratin
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5 Mechanical Factors Mucous membranes Ciliary escalator – transport microbes trapped in mucus away from the lungs Lacrimal apparatus – washes eye Saliva – washes microbes off Urine – flows out Vaginal Secretions – flows out
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6 Mechanical Factors Ciliary escalator Lacrimal glands
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7 Chemical Factors Fungistatic fatty acids in sebum Low pH (3-5) of skin Low pH (1.2-3.0) of gastric juice Lysozyme in sweat, tears, saliva and tissue fluids
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8 Normal Microbiota Microbial antagonism – normal microbiota compete with pathogens for food and space. Also known as Competitive exclusion
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9 Formed Elements in Blood
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10 Leukocytes
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11 Leukocytes Neutrophils Phagocytic Basophils Produce histamine Eosinophils Toxic to parasites Monocytes Phagocytic as mature macrophages Lymphocytes Involved in specific immunity Mast cells Wandering macrophages that roam tissues Fixed macrophages in lungs, liver, bronchi
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12 Macrophage
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13 Phagocytosis
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14 Inflammation Redness
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MICRO 06 Lect 12 - LECTURES IN MICROBIOLOGY Host Defense...

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