Virology - MICROBIOLOGY LECTURES Viruses and Acellular...

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01/18/12 1 Viruses and Acellular Agents MICROBIOLOGY LECTURES Sofronio Agustin Professor
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01/18/12 2 Lesson Objectives: At the end of the lesson, the students should be able to: Describe the structures and components of viruses, viroids and prions. Describe the mechanism of infection and replication of bacteriophages and animal viruses. Understand association between viruses and cancer and the phenomenon of viral latency and persistent infections.
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01/18/12 3 Basic Terminology Viruses are obligate intracellular parasites and require living host cell genetic and metabolic machinery for reproduction. Viral genomes contain either DNA or RNA, not both. Nucleic acid enclosed in a protein coat called Capsid . Some are surrounded by membrane layer called Envelope, which may contain integral proteins such as Spikes. Tropism – property of viruses to infect specific host cells; determined by specific host receptors and viral glycoproteins.
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01/18/12 4 Viruses and Bacteria Compared Bacteria Rickettsias/ Chlamydias Viruses Intracellular Parasite No Yes Yes Genome Both DNA & RNA Both DNA & RNA DNA or RNA Passage through bacteriologic filters No May pass through Yes Sensitive to Antibiotics Yes Yes No Sensitive to Interferon No No Yes
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01/18/12 5 Virus Sizes and Shapes
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01/18/12 6 Helical Viruses
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01/18/12 7 Enveloped Helical Virus
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01/18/12 8 Polyhedral Viruses An ICOSAHEDRON is a polygon with 12 triangular facets and 12 corners
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01/18/12 9 Enveloped Icosahedral Virus
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01/18/12 10 Complex Viruses Bacteriophages have icosahedral heads, sheathed tail and tail fibers for host cell attachment.
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