3_KIN_Enz+EQ

3_KIN_Enz+EQ - ENZYMES Enzymes are biological catalysts....

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
ENZYMES Enzymes are typically large protein molecules or combinations of proteins with other molecules. Enzymes are produced by organisms to accelerate and to control reaction rates. Enzymes are biological catalysts. MJ Bojan Chem 112 1
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
ENZYMES Lock and Key Model Reactant called substrate The region where the substrate/s bind is called the active site . active (binding) site How do enzymes work? E + S ES E + P MJ Bojan Chem 112 2
Background image of page 2
ENZYMES Enzymes are superior to man-made catalysts 1. More efficient. Speed up rates by factors of ~ 10 6 or more 2. Absolute specificity The active site depends on the enzyme conformation (shape). 3. Regulated: Rate can be controlled by changing enzyme activity. Enzyme Activity depends on Concentration of substrate Temperature pH MJ Bojan Chem 112 3
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
1. Enzymes are more efficient. 1. Enzyme active sites are ideally suited for transition state binding (lowers E a by lowering the energy of the transition state) Enzyme-substrate complex stabilizes the transition state 2. Juxtaposition of reactants high effective concentration (increases A) Each factor enhances rate by 10 5 lysozyme Nature’s catalysts – how do they increase rates by > 10 10 MJ Bojan Chem 112 4
Background image of page 4
Enzyme specificity The active site depends on the enzyme conformation (shape). If this shape is altered,
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 18

3_KIN_Enz+EQ - ENZYMES Enzymes are biological catalysts....

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online