Practice Final - Name_ Final Exam Monday, December 13, 2010...

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Name_________________ Final Exam Monday, December 13, 2010 1. Lipitor is a miracle drug that is used to lower cholesterol levels and is the best-selling drug in the world. a. Identify all functional groups. Classify as primary, secondary, or tertiary where relevant. b. How many stereoisomers of Lipitor are possible? c. In the biologically active stereoisomer of Lipitor, all stereocenters have the ( R ) configuration. Using wedge-dash notation, alter the structure below to depict the all-( R ) stereoisomer. c. The IR spectrum of Lipitor has distinctive absorptions at 3500 (broad), 1760 (strong), and 1650 (strong) cm -1 . Identify which functional group is responsible for each absorption, and briefly explain why. d. Lipitor is actually administered as its calcium salt by treating it with Ca(OH) 2 . Indicate which proton in Lipitor is the most acidic by putting a box around it.
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Name_________________ 2. Nitrosomethane (CH 3 NO) is a highly reactive molecule. a.
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This note was uploaded on 01/18/2012 for the course CHEM 335A taught by Professor Michael during the Fall '11 term at University of Washington.

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Practice Final - Name_ Final Exam Monday, December 13, 2010...

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