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Unformatted text preview: efficient synthesis of Apetinil from the following starting material. You may use any reagents that you wish. Do not use the same reaction twice . You do NOT need to show the mechanism. Just provide appropriate reagents and necessary synthetic intermediates. NH Apetinil (a) C 6 H 5 CH 2 COCH 3 (b) CH 3 Br CHEM 239A page 3 Name . 3. (30) ) (a) When 6-chloropurine is heated with aqueous sodium hydroxide, it is quantitatively converted to hydroxanthine. Suggest a reasonable mechanism. N N N N H Cl NaOH, H 2 O heat N NH N N H O 6-Chloropurine Hypoxanthine (b) Predict the major product(s) for each of the following reactions. If more than one product is expected, please put all of them in the box. (i) CH 2 CN Cl H 2 O, acetic acid H 2 SO 4 , heat (ii) O O O water heat (iii) CH 3 Br NaNH 2 liquid ammonia...
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This note was uploaded on 01/19/2012 for the course CHEM 239 taught by Professor Sasaki during the Summer '06 term at University of Washington.
- Summer '06