Glutamic acid ionization

Glutamic acid ionization - Part A: pKa 1 =2.10 pKa 2 =4.07...

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O OH NH 3 O O H pKa 1 pKa 2 pKa 3 O O NH 3 O O H O O NH 3 O -O O O NH 2 O -O + + + O OH NH 3 O O H O O NH 3 O O H O O NH 3 O -O O O NH 2 O -O O O NH 3 O O H O O NH 3 O -O + + + + + = = = EXAMPLES OF IONIZATION STATES OF GLUTAMIC ACID GLUTAMIC ACID – an acidic amino acid The major ionic species are shown at the pH’s where they would occur in Part A. The major species when pH=pKa are shown in Part B.
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Unformatted text preview: Part A: pKa 1 =2.10 pKa 2 =4.07 pKa 3 =9.47 pH<pKa 1 pH=pI=3.09 pH=6.77 pH>pKa 3 pH=1 (pKa 2 +pKa 3 )/2=3.09 (pKa 2 +pKa 3 )/2=6.77 pH=11 Part B: pH=pKa 1 =2.10 pH=pKa 2 =4.07 pH=pKa 3 =9.47...
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