Lecture1 - Bioinformatics: Definition? Lecture 1: Genes and...

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Lecture 1: Genes and the Genetic Code • Overview of Bioinformatics • Central Dogma • Genes and Genomes Bioinformatics: Definition? § Definition : Computational methods for collecting, organizing, and analyzing large amounts of biological data Biological Data Computational Algorithms Biological Model Biological Data § DNA sequence (A,T,G,C) § RNA sequence (A,U,G,C) § RNA abundance § Protein sequence (20 amino acids) § Protein abundance § Protein structure and post-translational modifications § Protein - protein interactions § Protein - DNA (RNA) interactions § Metabolic products and pathways Bioinformatics: Scope § DNA sequence analysis • Predicting genes • Sequence alignment • Phylogenetics § Gene expression analysis • DNA microarray data analysis • High-throughput sequencing § Protein sequence analysis • Sequence alignment • Secondary/tertiary structure prediction § Proteomics • Protein abundance, modifications, interactions § Metabolomics § Gene Networks / Mathematical Modeling
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Lecture1 - Bioinformatics: Definition? Lecture 1: Genes and...

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