Glodowski lec 18

Glodowski lec 18 - GENETICS LECTURE 18: MUTATIONS Mutation...

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GENETICS LECTURE 18: MUTATIONS Mutation = heritable change in the information content of a gene ~ change from what is observed most Mutation… With wild-type reference o Forward mutation = wild type to mutant o Reverse mutation = mutant to wild type True Revertant – back to wild type Suppressor Mutation – mutation at another site With organism and genome reference o Somatic Body cells, not gametes NOT heritable o Germ line Are heritable Mutations in gametes With scale reference… o Small scale = point mutations, single base pair change o Large scale = changes to whole chromosome. Deletions/Duplications… With amino acid reference… o MISSENSE – point mutation, changing amino acid. It CAN be neutral. o NONSENSE – change from a sense codon to a stop codon. Get truncated protein o SILENT – point mutation does not change the amino acid sequence. Only change in codon o FRAMESHIFT – insertion or deletion of 1 or 2 bp. Can end up with incorrectly made protein.
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This note was uploaded on 01/20/2012 for the course GENETICS 380 taught by Professor Glodowski during the Fall '08 term at Rutgers.

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Glodowski lec 18 - GENETICS LECTURE 18: MUTATIONS Mutation...

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