3b_Anaerobic_Glycolysis_SV_V2 - Besides PCr,...

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Unformatted text preview: Besides PCr, macronutrients can be used in phosphoryla7on. ADP + Pi Glucose/Glycogen, FA, AA CO2, H20, Heat ATP Complete breakdown of Carbohydrate Glucose 2 Pyruvates 1 Anaerobic Glycolysis •  Anaerobic breakdown of •  Produces ________ amounts of ATP, but at a _______ rate. –  1 glucose molecule can be quickly metabolized to yield _____ ATP. Note. Carbohydrates are the ONLY macronutrient that are broken down anaerobically. Anaerobic Glycolysis: Similar to Fig. 2.5 Where does it occur? 2 Anaerobic glycolysis (con’t): What if muscle glycogen is the energy substrate instead of glucose? •  Muscle glycogen can also be broken down via anaerobic glycolysis. 3 Glycolysis Tutorials • Tutorial 1: • hLp://highered.mcgraw ­hill.com/sites/0072507470/student_view0/ chapter25/anima7on__how_glycolysis_works.html • Tutorial 2: • hLp://www.science.smith.edu/departments/Biology/Bio231/ glycolysis.html • Tutorial 3: • hLp://www.northland.cc.mn.us/biology/biology1111/anima7ons/ glycolysis.html Ques7ons? •  What is the net gain of ATP during anaerobic glycolysis: –  If glucose is the substrate? –  If muscle glycogen is the substrate? –  If liver glycogen is the substrate? 4 Recall: •  What is the importance of NAD (Nico7namide Adenine Dinucleo7de)? For An. G. to con7nue to func7on and produce ATP at a very high rate: 5 What is the purpose of lactate produc7on? •  The purpose of lactate produc7on is to: –  __________ so that anaerobic glycolysis may con7nue producing ATP at a high rate. Benefits of lactate produc7on •  Temp. storage of H+ •  “Buys 7me” 6 Problems with Lactate •  Because it is very acidic, its accumula7on will: Fate of lactate: in the Cell •  When O2 becomes available, 7 Fate of lactate: that has diffused into blood stream •  It goes to________ –  Converted to glucose then to glycogen (via the __________) Glycolysis: Overview 1.  Occurs in the __________. 2.  Anaerobic Glycolysis does not require oxygen to recycle __________. 3.  Without oxygen present, pyruvic acid produced by glycolysis becomes __________. 4.  1 mole of muscle glycogen produces (nets) _____ moles of ATP; 1 mole of glucose produces (nets) _____ moles of ATP because 1 mole is used to convert glucose to glucose ­6 ­phosphate 5.  Combined, ATP ­PCr and anaerobic glycolysis provide the energy for the first _____ min of all ­out ac7vity. 8 ATP ­PCr and Glycoly7c Systems Key Points   ATP ­PCr system –  Pi is separated from PCr by what enzyme? –  Pi is combined with _____ to form ATP –  Energy yield: 1 mole of ATP per _____ mole of PCr •  Glycoly7c system –  Glucose or glycogen is broken down to _____. –  Without oxygen, pyruvic acid is converted to _____. –  1 mole of glucose yields _____ moles of ATP (gross) –  1 mole of glycogen yields _____ moles of ATP (gross) Energy Sources for the Early Minutes of Intense Exercise: Review The combined ac7ons of the ATP ­PCr and glycoly7c systems allow muscles to generate force in the absence of oxygen; thus, these two energy systems are the major energy contributors during the early minutes of high ­ intensity exercise. 9 ...
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