MCDB Christoffersen Lecture #4

MCDB Christoffersen Lecture #4 - MCDB Christoffersen...

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MCDB Christoffersen Lecture #4 Autosomal Recessive An autosomal recessive disorder means two copies of an abnormal gene must be present in order for the disease or trait to develop. o If you are born to parents who both carry an autosomal recessive change (mutation), you have a 1 in 4 chance of getting the malfunctioning genes from both parents and developing the disease. You have a 50% (1 in 2) chance of inheriting one abnormal gene. This would make you a carrier. o In other words, if four children are born to a couple who both carry the gene (but do not have signs of disease), the statistical expectation is as follows: o One child is born with two normal genes (normal) o Two children are born with one normal and one abnormal gene (carriers, without disease) o One child is born with two abnormal genes (at risk for the disease) Exceptions to Mendelian Inheritance Incomplete Dominance o A form of intermediate inheritance in which one allele for a specific trait is not completely dominant over the other allele. This results in a combined
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MCDB Christoffersen Lecture #4 - MCDB Christoffersen...

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