MCDB Christoffersen Lecture#7

MCDB Christoffersen Lecture#7 - MCDB Christoffersen Lecture...

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MCDB Christoffersen Lecture #7 DNA Fingerprinting Two types of DNA polymorphisms are used for DNA fingerprinting Single Nucleotide Polymorphisms (SNPs) o Inherited variation involving a single base – point mutations Short Tandem Repeats (STRs) o Short repetitive sequences occurring side by side on chromosomes, usually in noncoding regions o Commonly used in DNA fingerprinting Restriction Fragment Length Polymorphism (RFLPs) o a technique that exploits variations in homologous DNA sequences. o It refers to a difference between samples of homologous DNA molecules that come from differing locations of restriction enzyme sites, and to a related laboratory technique by which these segments can be illustrated. In RFLP analysis. o The DNA sample is broken into pieces (digested) by restriction enzymes and the resulting restriction fragments are separated according to their lengths by gel electrophoresis.
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Inborn Errors of Metabolism Genetic mutations may make protein dysfunctional Defects in proteins that are enzymes of metabolism can cause an inherited metabolic diseases
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MCDB Christoffersen Lecture#7 - MCDB Christoffersen Lecture...

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