Homework4

# Homework4 - BME 423 Fall 2011 HOMEWORK#4 Due before class...

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Page 1 of 5 BME 423 Fall 2011 HOMEWORK #4 Due before class Wednesday November 30 th , 2011 Please read the homework guidelines before starting your assignment. Tables necessary for completing this homework can be found in your textbook and are posted on Blackboard. 1. Nonparametric methods (13 points) A recently published study investigated whether continuous ingestion of astaxantin (AXT) could increase quantitatively choroidal blood flow velocity. In this study, 20 healthy volunteers were given 12 mg of AXT per day over a 4-week period. A technique called laser speckle flowgraphy (LSFG) was used to provide the square blur rate (SBR, in arbitrary units), which is a quantitative index of relative blood flow velocity. A subset of data is given in the following table (the data have been adapted). Is there significant evidence that treatment with AXT increases the macular SBR, i.e. the choroidal blood flow velocity, in this patient population? Subject Pre-treatment SBR (AU) 4-week post-treatment SBR (AU) 1 6.9 6.5 2 5.8 7.1 3 7.2 8.4 4 4.1 6.2 5 7.9 9.7 6 8.5 9.6 7 5.2 4.9 8 7.5 8.1 9 7.7 7.8 10 8.1 8.3 11 7.6 8.3 12 7.9 8.4 2. Nonparametric methods (13 points) A new study by Dr. T at USC is aimed at determining whether a person’s level of happiness is affected by his or her highest academic degree awarded by USC. The sample consisted of 12 subjects with a Bachelor’s degree, 10 subjects with a Master’s degree, and 6 subjects with a Ph.D degree. Subjects were asked to fill a detailed questionnaire based on which a happiness rating was assigned on a scale from 1-80. Based on these data (shown below), is there any evidence for a difference in happiness for people with bachelor’s degree, master’s degree, and Ph.D. degree? If there is a difference, you do not need to isolate which groups are different.

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Page 2 of 5 Happiness Level for subjects with different academic degrees Bachelor's Master's Ph.D. 30 34 29 48 74 38 57 37 79 60 69 53 42 59 46 54 52 65 68 73 67 61 63 56 45 49 55 35 3. Nonparametric methods (13 points) You are part of a team conducting a study on the effectiveness of aromatherapy in the treatment of anxiety in patients with severe dementia. Two groups of 20 patients each are treated with either Melissa officinalis essential oil (lemon balm), or placebo (sunflower oil). The oil is applied to their arms twice a day. The two patient groups are similar in every respect other than treatment. Patient
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• '06
• D'Argenio
• Statistical significance, Academic degree, statistically significant difference, nonparametric methods, blood flow velocity

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Homework4 - BME 423 Fall 2011 HOMEWORK#4 Due before class...

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