2 Friedel-Crafts Acylation

2 Friedel-Crafts Acylation - Experiment #2 FriedelCra3s...

Info iconThis preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
Experiment #2 Friedel-Cra3s Acyla8on of Ferrocene
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background of Ferrocene Ferrocene - C 5 H 5 FeC 5 H 5 Kealy and Pauson – 1951 Wilkinson, Roseblum, Whi8ng, and Woodward Deduced structure sandwich compound i.e. metallocene
Background image of page 2
Background of Ferrocene Organotransi8on metal chemistry First example of Cyclopentadienyl Complex, Cp Cp group is used as stabilizing ligand Led to beQer methods of synthesis Thousands of Cp complexes have since been synthesized
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background of Ferrocene Characteris8cs of Ferrocene Orange, needle-like crystals Stability to water, air, and acid Ease of sublima8on Ease of acetyla8on; 10 6 more likely than Benzene
Background image of page 4
Friedel Cra3s Acyla8on Acyl group: Electrophile in this case is R–C Þ O (acylium ion) Reac8on of an aroma8c hydrocarbon with an acyl halide
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Mechanism of Friedel Cra3s Acyla8on
Background image of page 6
Ferrocene Acyla8on Ferrocene has been referred to as superaroma8c compound acetylated under milder condi8ons: phosphoric acid
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Product Purifca8on: Column Chromatograpy Chromatography involves the separa8on oF mixtures due to di±erences in the distribu8on coefficient oF sample components between 2 di±erent phases. One oF these phases is a mobile phase and the other is a sta8onary phase . Di±erent affinity oF these components in the mixture to the sta8onary phase causes the separa8on.
Background image of page 8
Liquid Column Chromatography A sample mixture is passed through a column packed with solid par8cles. With the proper solvents, packing condi8ons, some components in the sample will travel the column more slowly than others resul8ng in the desired separa8on.
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Elution Strength of Mobile Phase ( ε ) Elution strength is generally considered to be equivalent to polarity . A solvents elution strength depends on Intermolecular Forces between the solvent and the analytes and between the solvent and the stationary phase. A more polar (or more strongly eluting solvent) will move all of the analytes to a
Background image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 01/20/2012 for the course CHEM 325BL at USC.

Page1 / 25

2 Friedel-Crafts Acylation - Experiment #2 FriedelCra3s...

This preview shows document pages 1 - 11. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online