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Histology 11-1 - Histology Blood Contd Hemopoiesis...

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Histology 11/1/11 Blood Contd. - Hemopoiesis- hematopoiesis - Theory is that everything is from one hemopoietic (pleuropotent because has ability to become many types of stem cells) stem cell into… o Then become hemolymphoid (colony forming unit) Natural killer cell (don’t really need to know the following) T lymphocyte Memory b cell Maybe dendritic cell o Then become myeloid (colony forming unit) Underges mitosis and form most of the formed elements Karyocyte Platelets Erythrocyte progenitor Monocyte progenitor Neutrophils Basophils Monocytes - ONLY GOING TO FOCUS ON GENESIS OF RED BLOOD CELLS - Erythropoeisis o Proerythroblast First step, can only become an erythrocyte Stimulated by the hormone erythro poietin . Stains basophilic cytoplasm because of polyribosomes Euchromatic nucleus because transcribing rnas o Basophilic erythoblast Lots of polyribosomes When multiple ribosomes are transcribing same sequence euchromatic o Polychromatophilic erythroblast Nucleus becoming more heterochromatic o Normoblast (orthochromato) Less basophilic because ribosomes and mitochondria are breaking down o Polychromatophilic erythrocyte When nucleus expelled Polychromatic because of reticular mesh around it, stains a bit eosinophilic Also known as reticulocyte Maturation happens in the Maturation happens in the spleen Release can be stimulated by extreme oxygen debt sensed by kidney o during hypoxia, releases renal erythropoietic factor
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