CaseStudy_CellCycle

CaseStudy_CellCycle - Case Study: Cell Cycle Control...

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Case Study: Cell Cycle Control Mechanism
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Chemostat
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Chemostat
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Chemostat
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Chemostat
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Chemostat
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S DNA synthesis G2 G1 cell division + Metaphase Anaphase Telophase Prophase The cell cycle is the sequence of events whereby a growing cell replicates all its components and divides them more-or-less evenly between two daughter cells ...
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G1 G2 24/0 12 18 G1 M G2 S A T dusk Start Exit 6 dawn (Clock)
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Diversity of Cell Cycle Organization Slime Mold M G2 S A T Fission Yeast M G2 S T Size Control
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Diversity of Cell Cycle Organization Fission Yeast Fission Yeast wee mutant WT wee M G2 S A T G1 G2 S M T Size Control
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R S response (R) signal (S) linear Gene Expression Signal-Response Curve
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R S EP E R rate (dR/dt) S=0 S=8 S=16 response (R) signal (S) Protein Synthesis: Positive Feedback Bistability off on Griffith, J Theor Biol (1968)
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R S 2 Cooperative Binding S + S response (R) Signal (S) sigmoidal
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R Kinase RP ATP ADP H 2 O P i Protein Phosphorylation Phosphatase response (RP) Signal (Kinase) Goldbeter & Koshland, PNAS (1981)
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Cdc14 Universal Control Mechanism for the Eukaryotic Cell Cycle Cdk1 CycB DNA synthesis P P
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X Y X X Toggle Switches Homeostasis CycB Cdc25 CycB Cdh1 CycB APC CycB APC CycB CycB Cdc25 Cdh1
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CaseStudy_CellCycle - Case Study: Cell Cycle Control...

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