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StochasticSimulation

StochasticSimulation - Computational Science and...

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Computational Science and Engineering Stochastic Modeling in Systems Biology Yang Cao Department of Computer Science
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Computational Science and Engineering Lambda-phage affected E. Coli
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Computational Science and Engineering Highlight the lambda phage regulation cI P L P R N cro P RM cI Cro If cI wins, P R and P L are repressed and the cell enters lysogeny If Cro wins, P RM is repressed and the cells enters the lytic cycle
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Computational Science and Engineering A close up on the right promoter- operator region P RM
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Computational Science and Engineering cI must bind to OR1 to repress rightwards transcription cI represses P R – shuts off cro cI activates P RM – expression of cI P RM
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Computational Science and Engineering Cro must bind to OR3 to repress expression of repressor by P RM Cro represses P RM – shuts off cI expression P RM P RE
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Computational Science and Engineering Lambda-phage affected E. Coli Stochastic effects play an important role in lytic/ lysogenic decision network Arkin et al. 1997, 1998 Lysis Lysogeny
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Computational Science and Engineering Chemical Reacting System
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Computational Science and Engineering A General Question
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Computational Science and Engineering Molecular Dynamics
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Computational Science and Engineering Some Facts about Cell (got from Mark Paul)
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Computational Science and Engineering
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Computational Science and Engineering
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Computational Science and Engineering Characteristics of the System
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Computational Science and Engineering One Reasoning (but not a proof)
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Computational Science and Engineering
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