StochasticSimulation

StochasticSimulation - Computational Science and...

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Unformatted text preview: Computational Science and Engineering Stochastic Modeling in Systems Biology Yang Cao Department of Computer Science Computational Science and Engineering Lambda-phage affected E. Coli Computational Science and Engineering Highlight the lambda phage regulation cI P L P R N cro P RM cI Cro If cI wins, P R and P L are repressed and the cell enters lysogeny If Cro wins, P RM is repressed and the cells enters the lytic cycle Computational Science and Engineering A close up on the right promoter- operator region P RM Computational Science and Engineering cI must bind to OR1 to repress rightwards transcription cI represses P R shuts off cro cI activates P RM expression of cI P RM Computational Science and Engineering Cro must bind to OR3 to repress expression of repressor by P RM Cro represses P RM shuts off cI expression P RM P RE Computational Science and Engineering Lambda-phage affected E. Coli Stochastic effects play an important role in lytic/ lysogenic decision network Arkin et al. 1997, 1998 Lysis Lysogeny Computational Science and Engineering Chemical Reacting System Computational Science and Engineering A General Question Computational Science and Engineering Molecular Dynamics Computational Science and Engineering Some Facts about Cell (got from Mark Paul) Computational Science and Engineering Computational Science and Engineering Computational Science and Engineering Characteristics of the System Computational Science and Engineering One Reasoning (but not a proof) Computational Science and Engineering Propensity Function vs the Reaction Rate...
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StochasticSimulation - Computational Science and...

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