18 - 3D CRT - 3-D Conformal Radiation TherapyTarun K Podder...

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Unformatted text preview: 3-D Conformal Radiation TherapyTarun K. Podder, PhD, DABRDepartment of Radiation OncologyBrody School of MedicineLeo Jenkins Cancer CenterEast Carolina UniversityMarch 24, 2011Lecture # 18 (Ch. 19)1) Treatments based on 3-D anatomic information2) Conformal dose distributions3) Dose response modelling –TCP, NTCP3-D Conformal Radiation therapyTCP – tumor control probabilityNTCP – normal tissue complication probability3-D CRT system has-3-D description of Patient Anatomy3-D calculations 3D contours Beam divergenceScatterBlock ScatterInhomogenietesPenumbraTransmission, leakageAdequate dosimetric coverage3-D CRT continued-3-D matrix of dose pointsPlan analysis tools Dose Volumes histogramsModelling Normal Tissue complication probability (NTCP)Tumor Control Probability (TCP)3D Planning ProcessObtain a 3-D data set- CT Data Set- MR Data Set (Image registration)- PET Data Set (Image registration)Image segmentation - delineating targets (GTV, CTV, PTV) and normal structures slice-by-sliceDose calculation – uses CT images (CT #)MR FusionMR FusionICRU 50 VOLUME RECOMMENDATIONSGTVo The palpable orvisible extent of the tumorconstitutes the Gross Tumor Volume (GTV) CTVo The GTV and local margins for sub-clinical diseaseare the Clinical Target Volume (CTV)...
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18 - 3D CRT - 3-D Conformal Radiation TherapyTarun K Podder...

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