6715_Lecture1 - Lecture I PHYS 6715 Biomedical Physics 1....

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1 PHYS 6715 - Lecture I 1 PHYS 6715 Biomedical Physics Xin-Hua Hu Tel: 328-1864 hux@ecu.edu http://bmlaser.physics.ecu.edu PHYS 6715 - Lecture I 2 Lecture I Overview 1. What is biomedical physics? 2. Atomic and molecular physics 3. Classical theory of electromagnetic waves 4. Statistical physics of macroscopic systems 5. Radiation-matter interaction 6. Probe of structure and function PHYS 6715 - Lecture I 3 I-1 What is biomedical physics? What is physics? The science of matter and energy and of interactions between the two. What is biology? The science of life and of living organisms. What is physiology? The biological study of the functions of living organisms and their parts. What is medicine? The science of diagnosing, treating, or preventing disease and other damage to the body or mind. - American Heritage Dictionary (1997) What is biomedical physics? Study of the physics related to various biological systems at different levels of biomolecules, cells, tissues and human body or mind. PHYS 6715 - Lecture I 4 I-1 What is biomedical physics? The early days of scientific research study of biomechanics of human body by Leonardo da Vinci (1452-1519) PHYS 6715 - Lecture I 5 I-1 What is biomedical physics? The early days of scientific research study of electricity on frog legs by Luigi Galvani (1737-1798) and Alessandro Volta (1745-1827) PHYS 6715 - Lecture I 6 I-1 What is biomedical physics? The early days of scientific research study of calorimeter by measuring heat production due to respiration in mammal by Antoine L. Lavoisier (1743-1794) and Pierre-Simon de Laplace (1749-1827)
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2 PHYS 6715 - Lecture I 7 I-1 What is biomedical physics? The system scales of biophysics and biomedical physics linear scales # of atoms / molecules Molecules - 10 -10 ~ 10 -9 m1 0 0 ~ 10 2 atoms Macromolecules – 10 -9 ~ 10 -7 0 2 ~ 10 5 atoms Organelles – 10 -8 ~1 0 -6 0 2 ~ 10 4 molecules Cells – 10 -6 ~ 10 -4 m 10 ~ 10 2 organelles Tissues - 10 -3 ~ 10 -1 0 3 ~10 10 cells Human body ~1m 10 12 cells PHYS 6715 - Lecture I 8 I-1 What is biomedical physics? metabolic rate (body mass) 3/4 metabolic rate (kcal/hr) warm-blooded animals body mass (kg) Nature History , p. 57 (Nov. 2006) PHYS 6715 - Lecture I 9 I-1 What is biomedical physics? Linear sizes of biological systems PHYS 6715 - Lecture I 10 I-1 What is biomedical physics? Matter to be understood by quantum mechanics (non-relativistic or Schrodinger equation). PHYS 6715 - Lecture I 11 I-1 What is biomedical physics? Radiation / EM Waves to be understood by classical electrodynamics (Maxwell’s equations). PHYS 6715 - Lecture I 12 I-2 Atomic and molecular physics Schrodinger equation – structure of hydrogen atoms Here Ψ ( r , t)=wave function of the orbiting electron H= system Hamiltonian = 22 2 2 2 2 2 222 0 1 () 4 ee e U mm x y z r πε ∂∂∂ −∇ + = ++ − == (,) t iH t t ∂Ψ r r =
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3 PHYS 6715 - Lecture I 13 I-2 Atomic and molecular physics Schrodinger equation – structure of hydrogen atoms With The Schrodinger equation can be transformed into a time-independent form by substituting Ψ with or in spherical coordinates 2 (,) 1 all space td τ Ψ= r 22 2 0 1 {} ( ) ( ) 24 e e E mr φ πε −∇ = rr = 2 2 2 2 2 0 11 1 1 {[() ( s i n) ] } ( )( ) 2s i n s i n 4 e e rE mr r r r r r θ φφ θθ
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This note was uploaded on 01/21/2012 for the course PHYS 6720 taught by Professor Hu during the Spring '10 term at East Carolina University .

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6715_Lecture1 - Lecture I PHYS 6715 Biomedical Physics 1....

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