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Unformatted text preview: HLTH 101 Fall, 2011 TOPIC 9: INTRODUCTION TO CANCER This lecture will serve as our introduction to cancer. We will begin by discussing the current status of cancer as a disease: its incidence and prevalence, mortality and morbidity. We’ll see that the detection of cancer is a major issue in determining mortality rates that are meaningful for our understanding of the success or failure of treatment as well as of changes in the incidence rate due to changes in risk factors. To understand this issue, we’ll need to understand some of the types of bias that can result from screening practices. It is vital that you understand these biases, so be sure to attend the lecture and keep careful notes! We’ll then discuss some of the basic concepts of cancer derived from research over the past few decades. Much of this discussion will focus on terminology and definitions, and so you should expect to have to spend some time on remembering specific terms as well as understanding the underlying concepts. Be sure to download the figures referred to on the next page. They will be invaluable in helping you to understand the concepts. Note that the notes for much (but not all) of this lecture are available at the end of this file. Be sure to study them carefully after downloading the figures from the web. Supplemental Readings: 1. http://www.cancer.ca/Canada- wide/About%20cancer/Cancer%20statistics/PowerPoint%20slides.aspx?sc_lang =en This is a link to the Canadian Cancer Society’s website in general and to statistical data in particular. I’ll be showing many of the slides for statistics from 2011 (seen at the top part of the box in the middle of the page). You may wish to download them yourselves. You may prefer to have a hard copy of the report Canadian Cancer Statistics 2011, in which case you should go to the following link: http://www.cancer.ca/Canada- wide/About%20cancer/Cancer%20statistics.aspx?sc_lang=en and then click on the appropriate link for the pdf. 2. http://theoncologist.alphamedpress.org/cgi/reprint/8/6/539 This brief (2 page) editorial, from the journal The Oncologist , summarizes many of the points I will make in the lecture on the Impact of Cancer. HLTH 101 Fall, 2011 3. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mboc4.figgrp.4267 This is the graphic depicting the concepts, to be explained in the lecture, of anaplasia and monoclonality. 4. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=cmed6.chapter.4989 http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=metastasis&rid=cooper.secti on.2603#2607 http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=cooper.figgrp.2614 http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mboc4.figgrp.4284 These four links are very general introductions to the concepts of initiation, promotion, progression and metastasis. Be sure to click on the link on the left of the second reading for diagram Fig. 15.4, and be sure to make a copy of all of the drawings and figures in the other links....
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- Spring '08