Lecture+3-Tissue+Organization+and+Tissue+Repair+%28GSI+guest+lecture%29

Lecture+3-Tissue+Organization+and+Tissue+Repair+%28GSI+guest+lecture%29

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• Tissue Components • Cell and tissue types • Tissue dynamics and repair
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• Circulatory: heart, blood vessels, blood • Respiratory: nose, lungs, trachea, bronchi • Digestive: mouth, stomach, intestines • Urinary: kidneys, ureters, bladder, urethra Major Organ Systems of Human Body • Musculoskeletal: bone, cartilage, ligaments, tendons, skeletal muscle • Immune: spleen, thymus, lymphoid tissues • Nervous: brain, spinal cord, peripheral nerves • Endocrine: pancreas, testes, ovaries, hypothalamus • Reproductive: testes, ovaries • Integumentary: skin
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System, Organ and Tissue
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Tissue Tissue = Cells + extracellular matrix (ECM)± Fibroblasts embedded in collagen matrix
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and Organization ! Skeletal muscle Smooth muscle Nerve
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• Epithelial tissues • Connective tissues: Tissue Types bone, ligaments, fat • Other tissue types Muscular, nervous,±
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Example: Skin Epidermis: ~0.1 mm -keratinocytes Dermis: ~1 mm -fibroblasts -hair follicles - vascular, nerve, & immune cells Subcutaneous tissue: ~0.4-4 mm
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Functional Subunits of Tissue Aveolus Lung
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• >200 types • Epithelial cells: 2-D sheets, tightly onnected, cannot migrate, polar (basal/apical) Cell Types connected, cannot migrate, polar • Mesenchymal cells: alone, loosely connected, bipolar shape, can migrate individually
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•Muscular tissue: skeletal, cardiac and smooth muscle •Nervous tissue: brain, spinal cord, nerves (neurons, glial cells, Schwann cells, oligodendrocytes) landular tissue: liver; large Golgi complex More Cell TypesE •Glandular tissue: liver; large Golgi complex (packaging for secretion), endoplasmic reticulum (synthesis, processing), e.g., thyroid •Blood •Germ cells: sperm, egg •Sensory cells: Hair cells, olfactory
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• ECM is a molecular complex that has basic components including collagens and other glycoproteins, hyaluronic acid, proteoglycans, glycosaminoglycans, and elastin. • ECM harbors molecules such as growth factors,
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This note was uploaded on 01/21/2012 for the course BIOE 116 taught by Professor Various during the Fall '10 term at University of California, Berkeley.

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Lecture+3-Tissue+Organization+and+Tissue+Repair+%28GSI+guest+lecture%29

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