Lecture+4--cell+expansion+limit

Lecture+4--cell+expansion+limit - The Limit of Cell...

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The Limit of Cell Expansion • Cell number: an important parameter for therapies • Cell Expansion potential • Hayflict limit • Telomere elomerase Telomerase • Microenvironment Reading: Chapter 1; 5.1 How Many Cells are in Our Body? unctional subunits: ~100 500- 000 Functional subunits: 100 m, 500 1000 cells • Cell density in most of the tissue: ~1-3 billion/ml; • Organ ~ 10 9 -10 11 or a 70 kg person (~70,000 ml), ~100 For a 70 kg person ( 70,000 ml), 100 trillion (10 14 ) cells in the body How Many Cells are required for therapies? • Cell- and tissue-type dependent • Tens of millions to a few billions Cell Number: Bone Marrow Transplant BMT: 40,000 cases in 1996 Applications: Therapies for genetic diseases (e.g., leukemia, sickle cell disease) and cancer patients (after radio- and chemo-therapies) Bone marrow: 500-1000 billion cells; most prolific tissue, producing 400 billion cells/day and 10 16 cells over a life time BMT: billions of cells
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Example: Bone Marrow Transplantation Aspirate bone marrow Bone marrow herapy Bone marrow transplantation
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Lecture+4--cell+expansion+limit - The Limit of Cell...

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