Lecture+7-reprogramming - 1. Kinetic Model of Cell...

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1. Kinetic Model of Cell Differentiation 2. Reprogramming Somatic Cells into Pluripotent Cells Somatic cell nuclear transfer Genetic reprogramming (induced pluripotent pg g ( pp stem cells) Kinetic Model of Cell Differentiation 1 2 3 N-1 N Stem cell Progenitor cell Ref #1: p.97 Epigenetic Landscape: A Metaphor of Cell Differentiation Somatic Cell Nuclear Transfer The steps involve removing the DNA from an oocyte y (unfertilized egg), and injecting the nucleus which contains the DNA to be cloned. In rare instances, the newly constructed cell will divide normally, replicating the new DNA while remaining in a pluripotent state. If the cloned cells are placed in the uterus of a female mammal, cloned organism develops in rare instances This is how Dolly a cloned organism develops in rare instances. This is how Dolly the Sheep and many other species were cloned. Alternatively, if cells are extracted from the cloned cells during very early embryonic stages (blastocyst or morula), embryonic stem cells can be created.
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Lecture+7-reprogramming - 1. Kinetic Model of Cell...

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