Lecture+8-reprogramming+and+therapies

Lecture+8-reprogramming+and+therapies - irect Reprogramming...

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Unformatted text preview: irect Reprogramming to Specific Cell Types 2. Examples of Stem Cell Therapies 1. Direct Reprogramming to Specific Cell Types Direct Reprogramming from Pancreatic Cells to -Islet Cells Three transcriptional factors: gn3 (Neurog3) Ngn3 (Neurog3) Pdx1 Mafa Nature 455, 627-632 (2 October 2008) Direct Reprogramming from Fibroblasts to Cardiomyocytes Reduce 14 genes to 3: Gata4 Mef2c Tbx5 Cell. 2010 Aug 6;142(3):375-86. Direct Reprogramming from Fibroblasts to Neurons Reduce 19 genes to 3: Ascl1 Brn2 (also called Pou3f2) Myt1l T Vierbuchen et al. Nature 000, 1-7 (2010) Examples of Stem Cell Therapies Examples of Stem Cell Therapies reatment of blood diseases ( SC Treatment of blood diseases (iPSC) Spinal cord regeneration: using human embryonic stem cell-derived oligodendroglial progenitors epairing ischemic heart muscle: Repairing ischemic heart muscle: mesenchymal stem cells, CD34+ bone marrow cells, embryonic stem cell-derived cardiomyocytes...
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This note was uploaded on 01/21/2012 for the course BIOE 116 taught by Professor Various during the Fall '10 term at University of California, Berkeley.

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Lecture+8-reprogramming+and+therapies - irect Reprogramming...

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