1 Direct Reprogramming to Specific Cell Types2. Examples of Stem Cell Therapies1. Direct Reprogramming to Specific Cell TypesDirect Reprogramming from Pancreatic Cells to -Islet Cells Three transcriptional factors:•Ngn3 (Neurog3)•Pdx1 •MafaNature455, 627-632 (2 October 2008)Direct Reprogramming from Fibroblasts to Cardiomyocytes Reduce 14 genes to 3: •Gata4 •Mef2c•Tbx5Cell. 2010 Aug 6;142(3):375-86.Direct Reprogramming from Fibroblasts to Neurons Reduce 19 genes to 3: •Ascl1•Brn2 (also called Pou3f2) •Myt1lT Vierbuchenet al. Nature000, 1-7 (2010)
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