Lecture+17-Angiogenesis+and+Microvascular+Design+%28GSI+Guest+Lecture%29

Lecture 17-Angiogene - Angiogenesis and Angiogenesis and Microvascular Design Microvascular Design • Angiogenesis vs vasculogenesis ritical steps

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Unformatted text preview: Angiogenesis and Angiogenesis and Microvascular Design Microvascular Design • Angiogenesis vs. vasculogenesis ritical steps in angiogenesis • Critical steps in angiogenesis • How to inhibit/promote angiogenesis • Microvascular design Angiogenesis and Vasculogenesis Angiogenesis and Vasculogenesis Angiogenesis and Vasculogenesis Angiogenesis and Vasculogenesis Vasculogenesis: A process that creates the primary network of vascular endothelial cells that will ecome major blood vessels. become major blood vessels. Angiogenesis: A process that remodels vascular network into the small new blood vessels or capillaries. Endothelial Cells (EC) Endothelial Cells (EC) Angiogenesis Angiogenesis • Tumor Tumor • Wound healing Wound healing ell transplantation ell transplantation • Cell transplantation Cell transplantation • Artificial tissue and organ Artificial tissue and organ Highlights in Angiogenesis History Highlights in Angiogenesis History • 1787 - British surgeon Dr. John Hunter first uses the term 'angiogenesis' (new blood vessel growth) • 1971 - Surgeon Dr. Judah Folkman hypothesizes that tumor growth is dependent upon angiogenesis. • 1975 - The first angiogenesis inhibitor is discovered in artilage (TNP 0) cartilage (TNP-70) • 1984 - The first angiogenic factor (basic fibroblast growth factor, bFGF) is purified. • 1989 - One of the most important angiogenic factors, vascular endothelial growth factor (VEGF), is discovered. • 1997 - First angiogenesis-stimulating drug (Regranex) is FDA-approved for treatment of diabetic foot ulcers Critical Steps in Angiogenesis Critical Steps in Angiogenesis First Phase First Phase-Signaling Signaling • Diseased or injured tissues produce and release angiogenic growth factors (proteins) that diffuse into the nearby tissues...
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This note was uploaded on 01/21/2012 for the course BIOE 116 taught by Professor Various during the Fall '10 term at University of California, Berkeley.

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Lecture 17-Angiogene - Angiogenesis and Angiogenesis and Microvascular Design Microvascular Design • Angiogenesis vs vasculogenesis ritical steps

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