Lecture+21-23-ECM - Extracellular Extracellular Matrix...

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Extracellular Matrix Extracellular Matrix (ECM) (ECM) ECM components ECM synthesis and degradation ECM receptors Mechanical property of ECM ECM is a molecular complex that has basic components collagens and other glycoproteins, hyaluronic acid, proteoglycans, glycosaminoglycans, and Extracellular Matrix (ECM) elastins. ECM harbors molecules such as growth factors, cytokines, matrix-degrading enzymes, and their inhibitors. Examples of extremes: Tissues are composed of cells and extracellular Matrix (ECM) Connective tissues: mostly ECM Epithelial tissues: mostly cells Fibrous proteins • Structural: collagen, elastin, etc.(tensile) • Adhesive: fibronectin, laminin, etc. Two main classes of macromolecules in ECM Glycosaminoglycans and proteoglycans (highly negatively charged polysaccharide chains, resist compressive force) • Hyaluronan • Chondroitin sulfate and dermantan sulfate • Heparin sulfate and heparin • Keratin sulfate
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Collagen • Collagen(s) is the most abundant protein , forming 1/3 of total protein content in the body.
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Lecture+21-23-ECM - Extracellular Extracellular Matrix...

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