Lecture+25+Synthetic+materials - Biomaterial Scaffolds...

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Biomaterial Scaffolds Ref #1. Ch 15-16 1. Biomaterial properties 2. Synthetic materials: polymers 3. Tailor the materials 1.1. Surface properties • Cell-surface interactions 1. Biomaterial Properties Non-Specific: vander Waals forces, electrostatic forces, solvation forces, steric forces Specific: receptor-ligand binding • Protein adsorption: electrostatic forces and hydrophobic interactions rotein sistant surfaces: ioinert e g polyethylene glycol Protein-resistant surfaces: bioinert, e.g., polyethylene glycol (PEG), hydrophilic, high flexibility, steric repulsion • Topography • Surface characterization: x-ray photoelectron spectroscopy 1.2. Bulk properties Ionic bonding, covalent bonding, metallic bonding 1. Biomaterial Properties 1.3. Mechanical properties Matching with native tissues, elastic/viscoelastic 1.4. Thermal properties: e.g., thermo-sensitive hydrogels poly(N- isopropyl acrylamide) (PNIPAM) with phase transition temperature between 28-32ºC 1.5. Electrical properties: e.g., polyvinylidene fluoride (PVDF), piezoelectric property Example: PVDF
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1.6. Biological properties
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Lecture+25+Synthetic+materials - Biomaterial Scaffolds...

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