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Lecture+30-Immunomodulation - Tissue Implantation...

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Immunomodulation and Immunoisolation • Biocompatibility is a fundamental characteristic at makes a substance very well tolerated so Tissue Implantation that makes a substance very well tolerated so as not to interfere with normal bodily functions on all levels (e.g., not producing a toxic, injurious, or immunological response in living tissue) • The immunological response is the body's way of defending itself against foreign substances that invade it to cause infection or disease Innate immunity (immediate, non specific sponses) Innate and Specific Immunity responses) Skin, mucosal epithelia: defensins Complement system Phagocytes (macrophage, neutrophil etc), natural killer cells Specific/adaptive immunity (specific responses, with memory) Antibodies Lymphocytes (B and T) consists of a system of serum proteins that can be activated by antibody-antigen Complement System complexes or carbohydrates on the surface of microorganisms to undergo a cascade of proteolytic reactions whose end result is the assembly of membrane attack complexes (form holes on membrane) Recruit phagocytic cells Complements and amplifies the action of antibodies
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Complement System The immune system protects the body from potentially harmful substances by recognizing nd responding to so- alled ntigens. Antigens a d espo d g to so ca edatg es Antigens are large molecules (usually proteins) on the surface of cells, viruses, fungi, or bacteria. Non-living substances such as toxins, chemicals, drugs, and foreign particles (such as a splinter) can be antigens. Even your own body cells have proteins that are antigens. Your immune system learns to see these antigens as "normal" and does not usually react against them. Lymphocytes: B lymphocytes (B cells) produce antibodies. Antibodies attach to a specific antigen and make it easier for pg the phagocytes to destroy the antigen. T lymphocytes (T cells) include cytotoxic T cells and elper T cells Cytotoxic T cells recognize the antigens helper T cells. Cytotoxic T cells recognize the antigens presented by Class-I major histocompatibility complex (MHC). Helper T cells provide the control of the immune response.
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Lecture+30-Immunomodulation - Tissue Implantation...

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