MSE-BioE+118+_10+L_11-12+Surface+Charact

MSE-BioE+118+_10+L_11-12+Surface+Charact - MSE/BioE 118...

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Unformatted text preview: MSE/BioE 118 Lecture #10 Surface Characterization Techniques (Temenoff & Mikos Chapter 7.6) Outline 1. Surface characterization of biomaterials 2. Ambient techniques Microscopy (scanning electron) Example: Failure analysis & corrosion testing Atomic force microscopy (AFM) Example: Aggrecan QCM-D Example: Protein adsorption 3. Ultrahigh vacuum techniques X-ray photoelectron spectroscopy (XPS or ESCA) Example: Intraocular Lens Secondary ion mass spectrometry (SIMS) Example: PET vascular graft Imaging with XPS/ESCA and SIMS Example: Cell patterning substrates Motivation for Biomaterials Characterization Develop quality control criteria Analysis of surface modification Assess the impact of sterilization on biomaterials surfaces Evaluate oxidation, degradation, corrosion, etc. Compare process methods Monitor surface active leachables exuded from the bulk Correlate surface chemistry and biological response From Biomaterials Evaluation (Ch. 7), Grainger and Healy Motivation for Biomaterials Characterization Develop quality control criteria Analysis of surface modification Assess the impact of sterilization on biomaterials surfaces Evaluate oxidation, degradation, corrosion, etc. Compare process methods Monitor surface active leachables exuded from the bulk Correlate surface chemistry and biological response From Biomaterials Evaluation (Ch. 7), Grainger and Healy Technique Physical Principle Measured Quantity Depth of Analysis Analytical Sensitivity XPS (ESCA) Photoelectron Effect: incident X-rays cause emission of electrons Kinetic energy ( or binding energy) of emitted core- level electrons 10-250 0.1 At% AES Incident electrons (e- ) cause emission of Auger e- s Kinetic energy of Auger...
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This note was uploaded on 01/21/2012 for the course C 118 taught by Professor Hayleylam during the Fall '11 term at University of California, Berkeley.

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MSE-BioE+118+_10+L_11-12+Surface+Charact - MSE/BioE 118...

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