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Unformatted text preview: MSE/BioE 118 Lecture #15 Protein Adsorption and Cell Adhesion to Surfaces (Temenoff & Mikos Chapter 7.1 & 7.2, and Chapter 9) 1. Cell-Substrate Adhesion Overview 2. Matrix composition and specificity 3. Cell Surface Receptors Receptor-ligand engagement Focal contact 4. Intracellular Events Receptor clustering Cytoskeleton Focal Contacts 5. Measuring Cell-substrate adhesion 6. Design Example: Surface Modification of Polystyrene Oxygen Plasma Treatment Protein Adsorption and Cell Adhesion Protein Adsorption and Cell Adhesion to Surfaces 1. Cell-substrate adhesion Why is cell adhesion important? A number of biological processes depend on cell adhesion Inflammation Wound healing Metastasis Development Regeneration of tissues and organs For biomaterials, biosensors, bioreactors, cell affinity chromatography Attachment to the device Fixation of the device Population kinetics on the device Overall biological performance The Cell-ECM Microenvironment Pol ock, J., and Healy, K.E., Biomimetic and Bio-responsive Materials in Regenerative Medicine: Intel igent Materials for Healing Living Tissues, In Strategies in Regenerative Medicine , M. Santin (Ed.), Springer, 2009 Matrix Proteins...
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- Fall '11