MSE-BioE+118+_11+L_21-22+Tissue+Rxn+W

MSE-BioE+118+_11+L_21-22+Tissue+Rxn+W - MSE/BioE 118...

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Unformatted text preview: MSE/BioE 118 Lectures # 21-22 Host Reactions to biomaterials: soft tissue implants Temenoff and Mikos (Chapters 10 & 11) 1. Wound healing • Acute inflammation • Chronic inflammation • Granulation tissue • Foreign body reaction • Fibrosis Host Response (local and systemic) Initial Events Inflammation Immunological Enzymatic/biochemical Bacterial Neoplasia (cancer) Corrosion Fatigue Fracture Degradation Adsorption Absorption Resorption Material Response Host Reactions to biomaterials: soft tissue implants 1. Wound healing Host Response (local and systemic) Initial Events Inflammation Immunological Enzymatic/biochemical Bacterial Neoplasia (cancer) Corrosion Fatigue Fracture Degradation Adsorption Absorption Resorption Material Response Host Reactions to biomaterials: soft tissue implants 1. Wound healing Host Response (local and systemic) Initial Events Inflammation Immunological Enzymatic/biochemical Bacterial Neoplasia (cancer) Corrosion Fatigue Fracture Degradation Adsorption Absorption Resorption Material Response Host Reactions to biomaterials: soft tissue implants 1. Wound healing Wound healing Ratner, Biomaterials Science Ch. 4.2 Host Reactions to biomaterials: soft tissue implants 1. Wound healing • Acute inFammation I • Chronic inFammation CE • Granulation tissue CE • ¡oreign body reaction CE • ¡ibrosis - capsule formation R Cellular events Initial events Remodeling Implant size, shape, chemistry Intensity and duration Response Time (days) CE CE I - Initial events/inflammation CE - Cellular events R - Remodeling CE I I I R R R low reactivity high reactivity Host Reactions to biomaterials: soft tissue implants Wound healing kinetics 1. Wound healing Ratner, 4.2 Temenoff & Mikos Fig. 11.1 Acute infammation- exudate NonspeciFc response to tissue damage Trauma In¡ection Intrusion o¡ ¡oreign material Toxicity Usually associated with blood contact, coagulation, and immune response Capillary dilation and increase in permeability o¡ endothelial cells allows ¡or fuid, blood-based protein, and cells to enter the damaged area ∆ P ~ 15 mm Hg Redness (rubor) RBC monocytes Swelling (tubor) EC¢ proteins Rapid Events Acute infammation Polymorphonuclear leukocytes (PMNs) • Neutrophils- role in phagocytosis Recognition and attachment EngulFment Killing or degradation (respiratory burst) Receptors activated by chemical mediators (Table 3) Example Physisorbed IgG Phagocytosis depends on size O 2 • H 2 O 2- Enzymes Acute infammation O 2 • H 2 O 2- Ratner, Biomaterials Science 4.2 Acute infammation Courtesy ProF. J. Anderson, CWRU, Cleveland ePT¡E vascular graFt Chronic infammation Monocytes - blood borne • Macrophage (ø) phagocytosis chemical mediators cytokines stimulate cell growth migration, diFFerentiation, and tissue remodeling • ¡oreign body giant cells (¡BGC) ¡usion oF ø to create multinucleated cells Major diFFerence between PMN’s and monocytes is the size and type oF particle they can phagocytize Chronic infammation Controlled Release Microsphere Courtesy ProF. J. Anderson, CWRU, Cleveland Foreign body reaction J. Black, Performance of Biological Materials , p. 130 Foreign body reaction Courtesy Prof. J. Anderson, CWRU, Cleveland Monocyte Macrophage Foreign Body Giant Cell Foreign body reaction Monocyte and Macrophage Adhesion, Morphology and Fusion Foreign body reaction Ratner, Biomaterials Science 4.2 Granulation tissue and foreign body reaction...
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This note was uploaded on 01/21/2012 for the course C 118 taught by Professor Hayleylam during the Fall '11 term at Berkeley.

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MSE-BioE+118+_11+L_21-22+Tissue+Rxn+W - MSE/BioE 118...

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