MSE-BioE+118+11+L_18-19+Drug+Delivery

MSE-BioE+118+11+L_18-19+Drug+Delivery - MSE/BioE 118...

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Unformatted text preview: MSE/BioE 118 Lectures #20-21 Drug Delivery Systems 1. General • Controlled drug release 2. Diffusion-Controlled Delivery Systems • Membrane-controlled devices 3. Chemically-Controlled Delivery Systems and Devices • Biodegradable polymers • Mechanisms of chemical degradation • Effect of degradation on material properties • Mechanisms of absorption and clearance 4. Design Example: Protein delivery from PLGA microspheres 5. Design Example: Drug-eluting Stents 6. Drug Delivery from Liposomes 1. General • Controlled drug release Ratner, Biomaterials Science 1. General • Controlled drug delivery (Robert Langer, MIT) Why? Site directed delivery of molecule allows for • Higher local doses • Minimal or little systemic distribution • Delivery of challenging molecules (e.g. short half-life) • New approaches to untreatable diseases Macromolecules for controlled delivery • Antibiotics • Steroids • Hormones • Growth and differentiation factors • Gene therapy (oligonucleotides, DNA) • Chemotherapy agents Pharmacokinetics & Toxicity Physicochemical Properties of Drug Design of Formation & Delivery Clinical Indications (acute/chronic) Adapted from Cleland and Langer, ACS v.567, 1994 • Biological Function • Biological activity Drug Stability in vitro / in vivo 1. General • Delivery formulation 1. General • Classification of controlled release systems Ratner, Biomaterials Science J = − D dC m dx J ¡ux in g/cm 2-sec D diffusion coef¢cient cm 2 /sec C m concentration in membrane g/cm 3 Fick’s ¢rst law J = DK Δ C l K partition coef¢cient l thickness of membrane J = EDK Δ C τ l E porosity (# pores/area) τ tortuosity 2. Diffusion-Controlled Delivery Systems2....
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MSE-BioE+118+11+L_18-19+Drug+Delivery - MSE/BioE 118...

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