MSE-BioE+118+2011+L14-15+Biomimetic+Mater+C

MSE-BioE+118+2011+L14-15+Biomimetic+Mater+C - MSE/BioE 118...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: MSE/BioE 118 Lecture #16 Biomolecular Materials 1. Biomolecule Grafting Biologically Modified or Biomimetic Materials Design example: Biomimetic IPNs - peptide grafting Design example: IPN - growth factor grafting (Sonic Hedgehog) The Cell-ECM Microenvironment Pol ock, J., and Healy, K.E., Biomimetic and Bio-responsive Materials in Regenerative Medicine: Intel igent Materials for Healing Living Tissues, In Strategies in Regenerative Medicine , M. Santin (Ed.), Springer, 2009 Ligand Presentation & Receptor Clustering Material Architecture Material Mechanics Saha, K., et al. , Current Opinion in Chemical Biology, 11 (4), 381-387 (2007) Designing Materials to Influence Biology Biologically Functional Materials ( Temenoff & Mikos 7.3 ) Biomolecule Grafting Temenoff & Mikos 7.10 Temenoff & Mikos 7.10 Bioconjugate Techniques Biologically Functional Materials ( Temenoff & Mikos 7.3 ) Biomolecule Grafting Temenoff & Mikos 7.10 Temenoff & Mikos 7.10 Bioconjugate Techniques NHS-Ester Reaction Scheme Maleimide Reaction Scheme Bioconjugate Techniques Example Reaction Scheme: coupling and amine to a thiol http://www.piercenet.com Bioinspired Materials Design Cell-binding domains can be incorporated into materials by a variety of methods A.) simple surface adsorption; B.) self-assembling monolayers; C.) grafting from polymer hydrogel; D.) incorporation as polymer backbone of a hydrogel; E.) amphiphile molecule adsorption; F.) surface grafting or modification; G.) grafted linear chains of semi-interpentrating network; and H.) grafting to interpenetrating network surface. Pol ock, J., and Healy, K.E., Biomimetic and Bio-responsive Materials in Regenerative Medicine: Intel igent Materials for Healing Living Tissues, In Strategies in Regenerative Medicine , M. Santin (Ed.), Springer, 2009 (A) (B) (C) Bioinspired Materials Design Method of Conjugation Affects the Bioavailability of the Ligand = Vitronectin = Albumin t Cytoskeletal Connections Integrin Subunit Peptide (e.g., RGD) Cell Membrane Prevent non-specific protein adsorption and materials fouling...
View Full Document

Page1 / 10

MSE-BioE+118+2011+L14-15+Biomimetic+Mater+C - MSE/BioE 118...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online