MSE-BioE+C118+_10+L_9-10+W+Surfaces

MSE-BioE+C118+_10+L_9-10+W+Surfaces - MSE/BioE 118 Lecture...

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MSE/BioE 118 Lecture # 9 (including lab material) Surfaces, Interfaces, and Wetting Outline 1. Overview of Interfacial Phenomena and Biomaterials Initial events Cell response 2. Surfaces and Interfaces What is a surface? Surface tension Surface tension = surface free energy Interfaces 3. Wetting Solid-liquid interface Young’s equation Contact angle measurements Critical surface tension 4. Paper Discussion Bain and Whitesides paper Host Response Initial Events Infammation Immunological Enzymatic/biochemical Bacterial Neoplasia (cancer) Corrosion Fatigue Fracture Degradation Adsorption Absorption Resorption Material Response Biomaterial Biomaterial Δ t Fouling of materials Cell behavior Host response proteins in solution 1. Overview of Interfacial Phenomena and Biomaterials Initial events 1 2 3
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Cytoskeletal Connections Cell Membrane Integrin Subunit Binding Site Vitronectin Albumin Integrins Biomaterial Biomaterial Cell response Protein α β RGD Cytoskeletal Connections Cell Membrane Integrin Subunit Binding Site Receptor-ligand engagement Biomaterial Dependent on Divalent cations (Mg 2+ , Ca 2+ ) Ligand signal Availability of the ligand 2. Surfaces and Interfaces What is a surface? Termination of atoms of a particular phase Termination of a crystal structure Termination of a amorphous phase Termination of a liquid Termination of condensed matter Results in atomic disorder at the surface 4 5 6
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What is a surface? Ratner 1.4 Surface Atoms Bulk Atoms 2. Surfaces and Interfaces What is a surface? Unsaturated bond at the surface Bulk = 4 nearest neighbors (nn) Surface= 3 nn Missing neighbors on one side of the surface leads to higher energy than internal atoms Ratner 1.4 2. Surfaces and Interfaces Surface tension Surface atoms are attracted toward the bulk to saturate the unsaturated bond Displacement of surface atoms into the bulk leads to a surface deFcient in atoms
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This note was uploaded on 01/21/2012 for the course C 118 taught by Professor Hayleylam during the Fall '11 term at University of California, Berkeley.

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MSE-BioE+C118+_10+L_9-10+W+Surfaces - MSE/BioE 118 Lecture...

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