MSE-BioE+C118+_10+L_17_18W+Blood+Perf

MSE-BioE+C118+_10+L_17_18W+Blood+Perf - MSE/BioE 118...

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Unformatted text preview: MSE/BioE 118 Lectures #17 & 18 (Chapter 13 Temenoff & Mikos) Blood Coagulation and Control of Blood-Materials Interactions Outline 1. Blood Coagulation Components of blood Platelet function Coagulation Control mechanisms 2. Blood-Materials Interactions What can we control? The Big picture Historical theories & approaches 3. Current Designs for Blood-Materials Interactions Empirical observations New Themes in Protein Adsorption Poly(ethylene glycol) [PEG] or poly(ethylene oxide) [PEO] Mechanisms of PEO interaction: entropic repulsion steric and fluctuation forces PEG-grafted surfaces Heparin-grafted surfaces 1. Blood Coagulation Components of blood What is blood made of? Number or % Cells Red blood cells (RBC) 4-5 million/mm 3 30-40% volume! White blood cells (monocytes) 6000-9000/mm 3 Lymphocytes 30-35% (WBC) Monocytes 3-7% Granulocytes Neutrophils 55-60% Eosinophils 2-5% Basophils 0-1% Platelets 200,000-400,000 /mm 3 ~ 0.30% volume Proteins > 200 known 1. Blood Coagulation Components of blood Alberts et al., Molecular Biology of the Cell 1. Blood Coagulation Components of blood ADP Ca 2+ serotonin Platelet factor 4 -thromboglobulin Fibrinogen Albumin Fibronectin von Willebrand factor (vWF) Ratner, Chapt. 4.6 1. Blood Coagulation Platelet function 1. Blood Coagulation Components of blood Alberts et al., Molecular Biology of the Cell 1. Blood Coagulation Components of blood ADP Ca 2+ serotonin Platelet factor 4 -thromboglobulin Fibrinogen Albumin Fibronectin von Willebrand factor (vWF) Ratner, Chapt. 4.6 1. Blood Coagulation Platelet function Leads to irreversible platelet aggregation Fused platelet thrombus Extension of contents: granules Platelet factor 4 (PF-4) -thromboglobulin( -TG) 1. Blood Coagulation Platelet function 1. Blood Coagulation Platelet function - Integrins 1. Blood Coagulation Platelet function Ratner, Chapt. 4.6 The Blood-Clotting Cascade XII XIIa XI XIa IX IXa VIIa VII X Xa X Thrombin Fibrinogen (monomer) Fibrin (polymer) Fibrin Clot VIIIa Va XIIIa Prothrombin INTRINSIC PATHWAY EXTRINSIC PATHWAY Surface Contact Fibrinogen plays a key role in thrombosis on biomaterial surfaces by promoting platelet adhesion and...
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This note was uploaded on 01/21/2012 for the course C 118 taught by Professor Hayleylam during the Fall '11 term at University of California, Berkeley.

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MSE-BioE+C118+_10+L_17_18W+Blood+Perf - MSE/BioE 118...

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