3 Regulation Operons1

3 Regulation Operons1 - Molecular Biology Part III...

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1 Molecular Biology Part III Regulation of Gene Expression A. Operons 1
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2 Mueller-Hill, B. 1996. The lac Operon
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3 Mueller-Hill, B. 1996. The lac Operon
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4 Transcriptional Regulation Main mechanism is to control access by RNA polymerase to the structural genes Other mechanisms may be added
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5 General Rules for Gene Regulation (1) 1. Synthesis (of gene product) occurs only when needed 2. Catabolic (breakdown) systems are inducible by their substrates Anabolic (synthetic) systems are repressible by their end products
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6 3. Most systems have more than 1 regulatory mechanism 4. If there is more than one catabolic pathway, the cell will use the pathway that produces ATP at the greatest rate General Rules for Gene Regulation (2)
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7 5. Proteins bring information to the genes about the status of cellular metabolism and conditions outside the cell General Rules for Gene Regulation (3)
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8
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9 Positive Regulation: No synthesis unless turned ON Negative Regulation: Constituitive synthesis unless turned OFF
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10 BUT:
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