amino acid stereochemistry, non-polar, polar, acidic and basic side chains, acid-base properties of amino acids and side chains, isoelectric point, electrophoresis, primary structure, cyanogen bromide, Edman degradation, solid phase peptide synthesis, peptide bond geometry, secondary structure, α-helix, β-pleated sheet, tertiary and quaternary structure. Objectives: • Identify an amino acid as non-polar, polar, acidic or basic. • Identify the stereochemistry of naturally occurring α-amino acids, including R/S and L/D configuration. Draw the correct stereochemistry of amino acids shown in staggered chain, line angle structures. • Describe the acid and base properties of amino acids. • Identify the approximate pKa values of amino and carboxylate groups in amino acids. • Identify the approximate pKa values of ionizable side chains. • Given the structure of an amino acid (side chain, plus amino and carboxylate groups), identify its protonation state and charges at a given pH. • Define the isoelectric point for an amino acid.
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